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KMID : 0377519900150030217
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Chung-Ang Journal of Medicine
1990 Volume.15 No. 3 p.217 ~ p.222
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Effects of Phosphodiesterase inhibitors on the Contractiloty of the Isolated Papaillary Muscle of the Guinea-pig
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Abstract
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Isolated electrically stimulated papillary muscle of the guinea-ping which was partially depolarized vith 19mM/L potassium Tyrode´s solution, was excised for the evaluation of phosphodiesterase inabitors. The experiments led to following results:
1) Theophylline exerts dose-dependant positive inotropic effects between concentration of 25 mg/L o 800 mg/L.
2) Xanthine exerts dose-dependant effect between concent ration of 10-6 M/L to 2.7 x 10´ M/L.
3) Amrinone exerts dose-dependent manner between concentration of 2.5 x 10-6 M/L to 8 x 10´5
4) Sulrnazole exerts dose-dependacy between concentration of I mg/L to 64 mg/L.
5) With low dose, papaverine promotes the contractility but inhibits the contractile force above
he concentration of 16mg/L.
These results indicate that all phosphodiesterase inhibitors exerts positive inotropic effects in guinea )ig papillary muscle.
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